How Does Cialis Work?

GlaxoSmithKline-cialisCialis is a common drug used to treat male impotence and in marketed by GlaxoSmithKline pharmaceutical company. At times reffered to as Tadalafil, Cialis falls under a group of drugs that inhibit an enzyme known as phosphodiesterase type 5 (PDE5). This action relaxes the blood vessels in the penile blood arteries allowing more blood to flow through. An individual is therefore able to maintain longer and harder erection when sexually simulated. Unlike other related drugs, the effects of Cialis are much stronger and also long-lasting. For instance, Viagra is effective for 4 to 6 hours while Cialis is effective for as many as 36 hours.

How Cialis Works

People experience erectile dysfunction when the blood flow into the penile arteries is either restricted or the nerves aren’t strong enough to hold it for long. Cialis deals with the problem in several ways. First, it relaxes the nerves and arteries a creating a smooth path for blood to flow through. Secondly, the drug increases the blood supply to the targeted regions. Thirdly, it strengthens the veins and walls allowing the penis to retain the blood for a longer period. By remaining in the blood system for a longer period, people using Cialis are able to experience several erections within a period of 36 hours.

Tadalafil_structureCialis starts by inhibiting an enzyme known as phosphodiesterase type 5 or simply PDE5. This enzyme prevents nitric oxide from reaching the smooth muscles in the penis scientifically known as the corpus cavernosum. In order to experience an erection, nitric oxide has to be present in the penile region after sexual stimulation. The substance stimulates cyclic nucleotide guanosine monophosphate (cGMP) which relaxes the muscles and veins and creates a smooth pathway for blood to flow. The higher the quantity of cGMP the harder and longer the erection will be. However, PDE5 enzyme stops the production and release of cGMP which means no or unsatisfactory erection.

Sexual Stimulation is needed

Sexual simulation is needed for Cialis to work since nitric oxide is only produced during and after arousal. Consuming the pills when there is no sexual simulation means the active ingredients have to nitric oxide to work with. This is why people are required to swallow the pills early enough to allow the ingredients to start working. As earlier stated, too much nitric oxide creates to high levels of cGMP leading to much harder and longer lasting erections. This can cause problems since too much blood will be flowing to the penile arteries. Men who don’t suffer from erectile dysfunction are discouraged from taking Cialis.

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